College of Pharmacy | Biopharmaceutical Sciences
College of Medicine | Ophthalmology and Visual Science
College of Engineering | Bioengineering | Chemical Engineering
UIC | OVCR | Research Integrity
Jason Buhrman
833 S. Wood Street (MC 865)
College of Pharmacy Building, Room 357
Chicago, IL 60612-7231
(312) 996-9765 Lab

Ph.D. Rotation: June 2010 - July 2010
Ph.D. Candidate: June 2011 - May 2015

Medical Scientist Training Program (MSTP)
Department of Biopharmaceutical Sciences

Dissertation Title: Recombinant protein immobilization and controlled-release
mediated by a non-covalent protein anchor
Defense Date: April 30, 2015

B.A., Biochemistry and Molecular Biology, Boston University, 2008
M.D./Ph.D. Student
, University of Illinois at Chicago, 2009 - Current

Awards
  1. 2012: Phi Kappa Phi Honor Society
  2. 2012: W.C. and May Preble Deiss Award for Biomedical Research 
  3. 2012-2014: Chancellor's Graduate Research Fellowship
  4. 2013: W.E. van Doren Scholar
  5. 2013: Golden Key Honor Society
  6. 2013-2015: CCTS TL1 Predoctoral Education for Clinical and Translational Scientists (PECTS) Fellowship
  7. 2014: Rho Chi Honor Society
  8. 2014: Multidisciplinary Oral Sciences Traing Program Research Forum, 2nd Place
  9. 2014: W.E. van Doren Scholar
  10. 2014: The Protein Society, Best Poster Award
  11. 2015: W.E. van Doren Scholar
  12. 2015: College of Pharmacy Research Day Predoctoral Poster Award, 2nd Place
  13. 2016: Dr. Erminio Costa Scholarship
Peer-Reviewed Manuscripts
  1. Passer BJ, Castelo-Branco P, Buhrman JS, Varghese S, Rabkin SD, Martuza RL. Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells. Cancer Gene Therapy, 16(7): 551-60, 2009. DOI:10.1038/cgt.2009.10 PMID: 2843507
  2. Castelo-Branco P, Passer BJ, Buhrman JS, Antoszczyk S, Marinelli M, Zaupa C, Rabkin SD, Martuza RL. Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer. Gene Therapy, 17(6): 805-10, 2010. DOI:10.1038/gt.2010.20 PMID: 3243306
  3. Kleijn A, Chen JW, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer-Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G. Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging. Clinical cancer research, 17(13): 4484-93, 2011. DOI:10.1158/1078-0432.CCR-11-0575 PMID: 3131449
  4. Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL. Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Molecular therapy, 20(1): 37-45, 2012. DOI:10.1038/mt.2011.187 PMID: 3255598
  5. Rayahin JE, Buhrman JS, Gemeinhart RA. Hybrid Nanocrystals: University of Kentucky US 2006/0280680A1, 22(3): 341-348, 2012. DOI & Pubmed
  6. Buhrman JS, Rayahin JE, Köllmer M, Gemeinhart RA. In-house preparation of hydrogels for batch affinity purification of glutathione S-transferase tagged recombinant proteins. BMC Biotechnology, 12: 63, 2012. DOI & Pubmed
  7. Zhang W, Fulci G, Wakimoto H, Cheema TA, Buhrman JS, Jeyaretna DS, Stemmer-Rachamimov AO, Rabkin SD, Martuza RL. Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL12 Enhances Anti-tumor Efficacy in Human Glioblastoma Models. Neoplasia, 15(6): 591-599, 2013. PMID: 23730207
  8. Köllmer M, Buhrman JS, Zhang Y, Gemeinhart RA. Markers Are Shared Between Adipogenic and Osteogenic Differentiated Mesenchymal Stem Cells. Journal of Developmental Biology and Tissue Engineering. 5(2): 18-25, 2013. DOI
  9. Buhrman JS, Cook LC, Rayahin JE, Federle MJ, Gemeinhart RA. Proteolytically activated anti-bacterial hydrogel microspheres. Journal of Controlled Release, 171(3): 288-295. DOI & Pubmed
  10. Buhrman JS, Cook LC, Rayahin JE, Federle MJ, Gemeinhart RA. Active, soluble recombinant melittin purified by extracting insoluble lysate of Escherichia coli without denaturation. Biotechnology Progress, 29(5): 1150-1157, 2013. DOI & Pubmed
  11. Zhang Y, Kölmer M, Buhrman JS, Tang MY, Gemeinhart RA. Arginine-rich, Cell Penetrating Peptide-microRNA Inhibitor Complexes Decrease Glioblastoma Migration Potential, Peptides, 58(1): 83-90, 2014. DOI & Pubmed
  12. Rayahin JE, Buhrman JS, Gemeinhart RA. Melittin, as a glutathione S-transferase fusion protein, maintains anti-inflammatory properties while diminishing toxicity, European Journal of Pharmaceutical Sciences, 65(1): 112-121, 2014. DOI & Pubmed
  13. Farrar CT, Buhrman JS, Liu G, Kleijn A, Lamfers ML, McMahon MT, Gilad AA, Fulci G. Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy. Radiology: 140251, 2015. DOI:10.1148/radiol.14140251 PMID: 25686366
  14. Rayahin JE, Buhrman JS, Zhang Y, Koh TJ, Gemeinhart RA. High and low molecular weight hyaluronic acid differentially influence macrophage activation, ACS Biomaterials Science and Engineering. 1(7): 481-493, 2015. DOI & Pubmed
  15. Jaishankar D, Buhrman JS, Valyi-Nagy T, Gemeinhart RA, Shukla D. Extended release of an anti-heparan sulfate peptide from a contact lens suppresses corneal Herpes Simplex Virus-1 (HSV-1) infection. Investigative Ophthalmology and Visual Science, 57(1): 169-180, 2016. DOI & Pubmed
  16. Zhang Y, Buhrman JS, Liu Y, Rayahin JE, Gemeinhart RA. Reducible Micelleplexes are Stable Systems for Anti-miRNA Delivery in Cerebrospinal Fluid, Molecular Pharmaceutics, online ahead of print, 2016. DOI & Pubmed
Book Chapters
  1. Buhrman JS, Cheema TA, Fulci G. Engineering herpes simplex virus for cancer oncolytic virotherapy, in Emerging cancer therapy : microbial approaches and biotechnological tools, Fialho A and Chakrabarty AM Editors. 2010, Wiley: Hoboken, N.J. p. 141-178.
Patents and Disclosures
  1. Gemeinhart RA, Tang MY, Buhrman JS. Recombinant MMP-sensitive Polymers for Therapeutic Delivery. Disclosed (DF121; 2/20/2012).
  2. Gemeinhart RA, Buhrman JS, Rayahin JE. Hydrogels for Delivery of Therapeutic Polypeptides, US 9,457,101B2 (October 4, 2016). USPTO
  3. Gemeinhart RA, Buhrman JS. Supramolecular Recombinant Polymers. Disclosed (DF136; 3/13/2012).
Abstracts and Proceedings
  1. Jason S. Buhrman, Pedro Castelo-Branco, Cecile Zaupa, Brent J. Passer, Samuel Rabkin, and Robert L, Martuza. An Oncolytic Virus armed with a Xenogeneic homologue of Prostatic Acid Phosphatase enhances anti-tumor efficacy in Prostate Cancer. Abstract. Accepted to MGH Annual Research Fellows Poster Award. 24 June 2008.
  2. Deva S. Jeyaretna, MD; Hiro Wakimoto, MD, PhD; Jason Buhrman, BA; Toshihiko Kuroda, MD, PhD; Samuel Rabkin, PhD; Robert L.Martuza, MD. Glioma Therapy Using an Oncolytic Herpes Simplex Virus Armed with Tumstatin. Abstract. AANS Annual Meeting 2009.
  3. Jason Buhrman B.A., John W. Chen MD/PhD, Samuel D. Rabkin PhD, Ralph Weissleder MD/PhD, Robert L. Martuza MD, Giula Fulci. Magnetic Resonance Imaging of Intratumoral Inflammation during Oncolytic Virotherapy. Abstract. MGH Scientific Advisory Committee. 2009.
  4. Fulci G, Kleijn A, Buhrman JS, Collins S, Lamfers M, Rabkin S, Martuza RL. Modulating IL-1 signaling during glioma oncolytic therapy. Neor-Oncology. Montreal, ON (November 2010).
  5. Kleijn A, Chen JW, Sun PZ, Buhrman JS, Rabkin SD, Weissleder R, Martuza RL, Lamfers ML, Fulci G. Magnetic resonnance imaging of viral spread and intratumoral inflammation during oncolytic vriotherapy. Neur-ONcology, Montreal, ON (November 2010).
  6. Cao Y, Buhrman JS, Tang MY, Gemeinhart RA. Design of Genetic Sequences Encoding a Matrix Metalloproteinase-2-Degradable Synthetic Recombinant Protein, IMSAlloquium, Aurora, IL (April 2011)
  7. Buhrman JS, Rayahin JE, Köllmer M, Gemeinhart RA. Using the glutathione s-transferase/glutathione interaction as a protein anchor in a controlled release delivery system for cancer treatment. 2012 College of Medicine Research Forum, Chicago, IL (November 2012).
  8. Buhrman JS, Rayahin JE, Köllmer M, Gemeinhart RA. Modeling the use of the glutathione s-transferase:-glutathione interaction as an anchor in a protein delivery system for cancer treatment., College of Pharmacy Research Day, Chicago, IL (February 2013).
  9. Köllmer M, Buhrman JS, Zhang Y, Gemeinhart RA. Markers Are Shared Between Adipogenic and Osteogenic Differentiated Mesenchymal Stem Cells, College of Pharmacy Research Day, Chicago, IL (February 2013).
  10. Rayahin JE, Buhrman JS, Gemeinhart RA. Degradable hyaluronic acid/interleukin-1 receptor antagonist wafers for osteoarthritis, College of Pharmacy Research Day, Chicago, IL (February 2013).
  11. Farrar CT, Buhrman JS, Liu G, Gilad AA, McMahon MT, Fulci G. Imaging Oncolytic virotherapy delivery using CEST reporter gene. International Society for Magnetic Resonance in Imaging, Salt Lake City, UT (April 2013).
  12. Farrar CT, Buhrman JS, Liu G, Kleijn A, Lamfers M, McMahon M, Gilad AA, Fulci G. Noninvasive imaging of oncolytic viruses through an MRI sensitive transgene. Replicating Oncolytic Virus Therapeutics. Quebec, QC (June 2013).
  13. Buhrman JS, Rayahin JE, Köllmer M, Gemeinhart RA. Using the glutathione S-transferase:glutathione interaction as a protein anchor in a controlled-release delivery system for cancer treatment. UIC Medical Scientist Training Program Retreat, Chicago, IL (August 2013).
  14. Rayahin JE, Buhrman JS, Gemeinhart RA. Melittin fusion protein and hyaluronic acid have augmented anti-inflammatory properties when combined. College of Medicine Research Day, Chicago, IL (November 2013).
  15. Buhrman JS, Rayahin JE, Gemeinhart RA. Recombinant Melittin Protein Therapy for the Treatment of High Grade Astrocytoma. College of Medicine Research Day, Chicago, IL (November 2013).
  16. Zhang Y, Liu Y, Buhrman JS, Gemeinhart RA. Redox Responsive Micelles for Codelivery of Drugs and Silencing RNAs. College of Pharmacy Research Day, Chicago, IL (March 2014).
  17. Buhrman JS, Rayahin JE, Gemeinhart RA. Recombinant Melittin as Protein Therapy for Treatment of High Grade Astrocytoma. College of Pharmacy Research Day, Chicago, IL (March 2014).
  18. Rayahin JE, Buhrman JS, Gemeinhart RA. Melittin Fusion Protein and Hyaluronic Acid Have Augmented Anti-Inflammatory Properties When Combined. College of Pharmacy Research Day, Chicago, IL (March 2014).
  19. Rayahin JE, Buhrman JS, Gemeinhart RA. Recombinant melittin protein loaded microspheres for treatment of high-grade astrocytoma. AICHE Midwest Regional Conference (Platform Talk), Chicago, IL (March 2014).
  20. Buhrman JS, Rayahin JE, Gemeinhart RA. Polymeric modulation of immune cell function. AICHE Midwest Regional Conference (Platform Talk), Chicago, IL (March 2014).
  21. Buhrman JS, Rayahin JE, Gemeinhart RA. Recombinant melittin protein therapy for the treatment of high grade astrocytoma.  Association for Clinical and Translational Sciences (April 2014).
  22. Buhrman JS, Rayahin JE, Gemeinhart RA. Recombinant melittin protein therapy for treatment of high grade astrocytoma. American Physician Scientists Association. Chicago, IL (April 2014).
  23. Buhrman JS, Rayahin JE, Gemeinhart RA. Recombinant melittin protein therapy for the treatment of high grade astrocytoma.  UIC Medical Scientist Training Program Retreat, Chicago, IL (June 2014).
  24. Buhrman JS, Rayahin JE, Gemeinhart RA. Delivering Recombinant Melittin for Treatment of High Grade Astrocytoma. International Symposium on Controlled Release of Bioactive Materials, Chicago, IL (July 2014).
  25. Rayahin JE, Buhrman JS, Gemeinhart RA. Melittin-GST fusion protein and hyaluronic acid have augmented anti-inflammatory properties when Combined. International Symposium on Controlled Release of Bioactive Materials, Chicago, IL (July 2014).
  26. Zhang Y, Liu Y, Buhrman JS, Gemeinhart RA. Exploring Redox Responsive Polymeric Drug Delivery System for Codelivery of Hydrophobic Drug and Silencing RNAs. International Symposium on Controlled Release of Bioactive Materials, Chicago, IL (July 2014).
  27. Buhrman JS, Rayahin JE, Zhang Y, Tang MY, Gemeinhart RA. Biologically responsive recombinant protein anchors for macromolecular drug delivery. 28th Annual Symposium of the Protein Society, San Diego, CA (July 2014).
  28. Akinrotimi D, Buhrman JS, Gemeinhart RA. Loading Proteins Throughout the Network of Glutathione-laden Hydrogels, Multidisciplinary Oral Sciences Traing Program Research Forum (Platform Talk), Chicago, IL (August 2014).
  29. Buhrman JS, Rayahin JE, Zhang Y, Tang MY, Gemeinhart RA. Biologically responsive recombinant protein anchors for macromolecular drug delivery. Annual Chicago Biomedical Consortium Meeting, Chicago, IL (October 2014).
  30. Buhrman JS, Rayahin JE, Zhang Y, Tang MY, Gemeinhart RA. Biologically Responsive Recombinant Protein Anchors for Macromolecular Drug Delivery. College of Medicine Research Day, Chicago, IL (November 2014).
  31. Rayahin JE, Zhang Y, Buhrman JS, Gemeinhart RA. Hyaluronan as a regulator of macrophage function: implications for inflammation and angiogenesis. Annual Meeting of the Society for Glycobiology, Honolulu, HI (November 2014).
  32. Buhrman JS, Rayahin JE, Zhang Y, Tang MY, Gemeinhart RA. Recombinant protein immobilization and controlled-release mediated by versatile, non-covalent protein anchor. College of Pharmacy Research Day, Chicago, IL (February 2015).
  33. Rayahin JE, Zhang Y, Buhrman JS, Tang MY, Gemeinhart RA. Hyaluronan as a regulator of macrophage function: implications for inflammation and angiogenesis. College of Pharmacy Research Day, Chicago, IL (February 2015).
  34. Zhang Y, Liu Y, Buhrman JS, Gemeinhart RA. Controlling miRNA Micelleplex Formation and Disassembly. College of Pharmacy Research Day, Chicago, IL (February 2015).
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