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Peer-Reviewed Publications
# Ref DOI Pubmed 57 Andrianopoulou A†, Sokolowski K†, Wenzler E, Bulman ZP, Gemeinhart RA. Assessment of antibiotic release and antibacterial efficacy from pendant glutathione hydrogels using ex vivo porcine skin. Journal of Controlled Release, 365(1): 936-949, 2024. 10.1016/j.jconrel.2023.12.008 3807060 56 Dial CF, Gemeinhart RA. Biophysical Characterization of Interactions between Serum Albumin and Block Copolymer Micelles. ACS Biomaterials Science and Engineering 8(7): 2899-2907, 2022. 10.1021/acsbiomaterials.2c00016 35767337 55 Sokolowski K, Pham H, Wenzler E, Gemeinhart RA. Glutathione Conjugated Hydrogels: Smart, Flexible Vehicles for Personalized Treatment of Bacterial Infections. Pharmaceutical Research 38(7): 1247-1261, 2021. 10.1007/s11095-021-03057-1 34117588 54 Langridge TD, Gemeinhart RA. Toward Understanding Polymer Micelle Stability: Density Ultracentrifugation Offers Insight into Polymer Micelle Stability in Human Fluids. Journal of Controlled Release 319(1): 157-167, 2020. 10.1016/j.jconrel.2019.12.038 34117588 53 Liu Y, Zhang Y, Chen S-N, Friesen JB, Nikolic D, Choules MP, McAlpine JB, Lankin DC, Gemeinhart RA, Pauli GF. The Influence of Natural Deep Eutectic Solvents on Bioactive Natural Products: Studying Interactions between a Hydrogel Model and Schisandra chinensisMetabolites. Fitoterapia 127: 212-219, 2018. 10.1016/j.fitote.2018.02.024 29474979 52 Zhang Y, Buhrman JS, Liu Y, Rayahin JE, Gemeinhart RA. Reducible Micelleplexes are Stable Systems for Anti-miRNA Delivery in Cerebrospinal Fluid. Molecular Pharmaceutics 13(6): 1791-1799, 2016. 10.1021/acs.molpharmaceut.5b00933 27177352 51 Jaishankar D†, Buhrman JS†, Valyi-Nagy T,Gemeinhart RA, Shukla D. Extended release of an anti-heparan sulfate peptide from a contact lens suppresses corneal Herpes Simplex Virus-1 (HSV-1) infection. Investigative Ophthalmology and Visual Science 57(1): 169-180, 2016. 10.1167/iovs.15-18365 26780322 50 Lu Y, Chen Y, Gemeinhart RA, Wu W, Li T. Developing nanocrystals for cancer treatment. Nanomedicine 10(16): 2537-2552, 2015. 10.2217/nnm.15.73 26293310 49 Rayahin JE, Buhrman JS, Zhang Y, Koh TJ, Gemeinhart RA. High and low molecular weight hyaluronic acid differentially influence macrophage activation. ACS Biomaterials Science and Engineering 1(7): 481-493, 2015. 10.1021/acsbiomaterials.5b00181 26280020 48 Zhang Y, Liu Y Sen S, Král P, Gemeinhart RA. Charged Group Surface Accessibility Determines Micelleplexes Formation and Cellular Interaction. Nanoscale 7(17): 7559-7564, 2015. 10.1039/C5NR00095E 25866141 47 Rayahin JE, Buhrman JS, Gemeinhart RA. Melittin, as a glutathione S-transferase fusion protein, maintains anti-inflammatory properties while diminishing toxicity. European Journal of Pharmaceutical Sciences 65(1): 112-121, 2014. 10.1016/j.ejps.2014.09.012 25240321 46 Zhang Y, Köllmer M, Buhrman JS, Tang MY, Gemeinhart RA. Arginine-rich, Cell Penetrating Peptide-microRNA Inhibitor Complexes Decrease Glioblastoma Migration Potential. Peptides 58(1): 83-90, 2014. 10.1016/j.peptides.2014.06.008 24969623 45 Zellander A, Zhao H, Kotecha M, Low, K-B, Gemeinhart RA, Wardlow M, Abiade J, Cho M. Characterization of pore structure in biologically functional Poly(2-hydroxyethyl methacrylate)-poly(ethylene glycol) diacrylate (PHEMA-PEGDA). PLOS One 9(5): e96709, 2014. 10.1371/journal.pone.0096709 24816589 44 Sharma V, Köllmer M, Szymusiak M, Nitsche LC, Gemeinhart RA, Liu Y. Toroidal-spiral particles for co-delivery of anti-VEGFR-2 antibody and irinotecan-a potential implant to hinder recurrence of glioblastoma multiforme. Biomacromolecules 15(3): 756-762, 2014. 10.1021/bm401550r 24460101 43 Zhang H, Wang X, Dai W,Gemeinhart RA, Zhang Q, Li T. Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis. Molecular Pharmaceutics 11(1): 226-233, 2013. 10.1021/mp4004018 24294887 42 Zhang Y, Wang ZJ, Gemeinhart RA. Progress in MicroRNA Delivery. Journal of Controlled Release172(3): 962-974, 2013. 10.1016/j.jconrel.2013.09.015 24075926 41 Buhrman JS, Cook LC, Rayahin JE, Federle MJ, Gemeinhart RA. Active, soluble recombinant melittin purified by extracting insoluble lysate of Escherichia coli without denaturation. Biotechnology Progress 29(5): 1150-1157, 2013. 10.1002/btpr.1784 23926061 40 Köllmer M, Popescu C, Manda P, Zhou L, Gemeinhart RA. Stability of Benzocaine Formulated in Commercial Oral Disintegrating Tablet Platforms. AAPS PharmSciTech 14(4): 1333-1340, 2013. 10.1208/s12249-013-0015-5 23990120 39 Hollis CP, Weiss HL, Leggas M, Evers BM, Gemeinhart RA, Li T. Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: Lessons learned of the EPR effect and image-guided drug delivery. Journal of Controlled Release 172(1): 12-21, 2013. 10.1016/j.jconrel.2013.06.03 23920039 38 Buhrman JS, Cook LC, Rayahin JE, Federle MJ,Gemeinhart RA. Proteolytically activated anti-bacterial hydrogel microspheres. Journal of Controlled Release 171(3): 288-295. 10.1016/j.jconrel.2013.06.023 23816641 37 Hollis CP, Weiss HL, Evers BM, Gemeinhart RA, Li T. In VivoInvestigation of Hybrid Paclitaxel Nanocrystals with Dual Fluorescent Probes for Cancer Theranostics. Pharmaceutical Research 31(6): 1450-1459, 2014. 10.1007/s11095-013-1048-x 23619595 36 Köllmer M, Buhrman JS, Zhang Y, Gemeinhart RA. Markers Are Shared Between Adipogenic and Osteogenic Differentiated Mesenchymal Stem Cells. Journal of Developmental Biology and Tissue Engineering 5(2): 18-25, 2013. 10.5897/JDBTE2013.0065 24013643 35 Zellander A,Gemeinhart RA, Djalilian AR, Makhsous M, Sun S, Cho MR. Desiging a Gas Foamed Scaffold for Keratoprosthesis. Material Science and Engineering C-Materials for Biological Applications 33(6): 3396-3406, 2013. 10.1016/j.msec.2013.04.025 23706226 34 Buhrman JS, Rayahin JE, Köllmer M, Gemeinhart RA. In-house preparation of hydrogels for batch affinity purification of glutathione S-transferase tagged recombinant proteins. BMC Biotechnology 12(1): 63, 2012. 10.1186/1472-6750-12-63 22989306 33 Ross AE, Tang MY, Gemeinhart RA. Effects of Molecular Weight and Loading on Matrix Metalloproteinase-2 Mediated Release from Poly(Ethylene Glycol) Diacrylate Hydrogels. The AAPS Journal 14(3): 482-490, 2012. 10.1208/S12248-012-9356-3 22535508 32 Zhang Y, Gemeinhart RA. Improving Matrix Metalloproteinase-2 Specific Response of a Hydrogel System using Electrophoresis. International Journal of Pharmaceutics 429(1-2): 31-37, 2012. 10.1016/j.ijpharm.2012.03.012 22440150 31 Köllmer M, Keskar V, Hauk TG, Collins JM, Russell B, Gemeinhart RA. Stem Cell-derived Extracellular Matrix Enables Survival and Multi-Lineage Differentiation within Superporous Hydrogels. Biomacromolecules 13(4): 963-973, 2012. 10.1021/bm300332w 22404228 30 Rayahin JE, Buhrman JS, Gemeinhart RA. Hybrid Nanocrystals: University of Kentucky US 2006/0280680A1. Expert Opinion on Therapeutic Patents 22(3): 341-348, 2012. 10.1517/13543776.2012.665877 22364361 29 Desai ES, Tang MY, Ross, A, Gemeinhart RA. Macroporous Hydrogel Scaffolds: A Platform for Cell Encapsulation. Biomedical Materials 7(2): 024108, 2012. 10.1088/1748-6041/7/2/024108 22455976 28 Shafiq MA, Gemeinhart RA, Yue BYJT, Djalilian AR. Decellularized Human Cornea for Reconstructing the Corneal Epithelium and Anterior Stroma. Tissue Engineering, Part C 18(5): 340-348, 2012. 10.1089/ten.TEC.2011.0072 22082039 27 Zhao RS, Hollis CP, Zhang H, Sun L, Gemeinhart RA, and Li T. Hybrid Nanocrystals: Achieving Concurrent Therapeutic and Bioimaging Functionalities Toward Solid Tumors. Molecular Pharmaceutics 8(5): 1985-1991, 2011. 10.1021/mp200154k 21812439 26 Bae M, Divan R, Suthar KJ, Mancini DC, Gemeinhart RA. Fabrication of PEG Hydrogel Particles for Pharmaceutics using Electron beam and Optical Lithography. Journal of Vaccuum Science and Technology-B 28(6): C6P24-C6P26, 2010. 10.1116/1.3517716 21423572 25 Kadakia A, Keskar V, Djilian A, Gemeinhart RA, Cho MR. Materials Characterization of Hybrid Superporous Scaffolds. Critical Reviews in Biomedical Engineering 36(5-6): 441-471, 2008. 10.1615/CritRevBiomedEng.v36.i5-6.50 20092432 24 Vartak DG, Lee BS, Gemeinhart RA. In vitro evaluation of functional interaction of integrin aVβ3 and matrix metalloprotease-2. Molecular Pharmaceutics 6(6): 1856-1867, 2009. 10.1021/mp900152t 19799453 23 Keskar V, Gandhi M, Gemeinhart EJ, Gemeinhart RA. Initial Evaluation of Vascular Ingrowth into Superporous Hydrogels. Journal of Tissue Engineering and Regenerative Medicine 3(6): 486-490, 2009. 10.1002/term.18 19526620 22 Gandhi M, Srikar R, Yarin AL, Megaridis CM, Gemeinhart RA. Mechanistic Examination of Protein Release from Polymer Nanofibers. Molecular Pharmaceutics 6(2): 641-647, 2009. 10.1021/mp800160p 19718809 21 Keskar V, Marion NW, Mao JJ, Gemeinhart RA. In VitroEvaluation of Macroporous Hydrogels to Facilitate Stem Cell Infiltration, Growth and Mineralization. Tissue Engineering, Part A 15A(7): 1695-1707, 2009. 10.1089/ten.tea.2008.0238 19119921 20 Gemeinhart RA. Digestive Enzyme Targeted Polymer Therapeutic: MIT WO 2007/103364 A2. Expert Opinion on Therapeutic Patents 18(9): 1085-1090, 2008. 10.1517/13543776.18.9.1085 19 Tauro JR, Lee BS, Lateef SS, Gemeinhart RA. Matrix Metalloprotease Selective Platinate Release from Hydrogel Matrices. Peptides 29(11) 1965-1973, 2008. 10.1016/j.peptides.2008.06.021 1865286 18 Guo C, Gemeinhart RA. Investigation of the mechanism of chitosan adsorption to poly(lactide-co-glycolide) nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 70(2): 597-604, 2008. 10.1016/j.ejpb.2008.06.008 18602994 17 Chaterji S, Gemeinhart RA. Enhanced Osteoblast-Like Cell Adhesion and Proliferation Using Sulfated Polymeric Scaffold. Journal of Biomedical Materials Research 83A(4): 990-998, 2007. 10.1002/jbm.a.31283 17584889 16 Vartak DG, Gemeinhart RA. Matrix metalloproteases: Underutilized Targets for Drug Delivery (Invited Review). Journal of Drug Targeting 15(1): 1-20, 2007. 10.1080/10611860600968967 17365270 15 Keskar V, Mohanty, PS, Gemeinhart EJ, Gemeinhart RA. Development of a local system for treatment of cervical cancer. Journal of Controlled Release 115(3): 280-288, 2006. 10.1016/j.jconrel.2006.08.014 17034891 14 Gemeinhart RA, Bare CM, Haasch RT, Gemeinhart EJ. Osteoblast-like cell attachment to and calcification of novel phosphate-containing polymeric substrates. Journal of Biomedical Materials Research 78A(3): 433-440, 2006. 10.1002/jbm.a.30788 16955553 13 Muni NJ, Qian H, Qtaishat NM, Gemeinhart RA, Pepperberg DR. Activation of membrane receptors by neurotransmitter released from temperature-sensitivehydrogels. Journal of Neuroscience Methods 151(2): 97-105, 2006. 10.1016/j.jneumeth.2005.06.029 16198001 12 Tauro JR, Gemeinhart RA. Matrix metalloprotease triggered local delivery of cancer chemotherapeutics from hydrogel matrixes. Bioconjugate Chemistry 16(5): 1133-1139, 2005. 10.1021/bc0501303 16173790 11 Tauro JR, Gemeinhart RA. Extracellular protease activation of chemotherapeutics from hydrogel matrices: A new paradigm for local chemotherapy. Molecular Pharmaceutics 2(5): 435-438, 2005. 10.1021/mp050028n 16196497 10 Tauro JR, Gemeinhart RA. Development of amine-containing polymeric nanoparticles. Journal of Biomaterials Science, Polymer Edition 16(10): 1233-1244, 2005. 10.1163/156856205774269539 16268250 9 Yan X, Gemeinhart RA. Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles. Journal of Controlled Release 106(1-2): 198-208, 2005. 10.1016/j.jconrel.2005.05.005 15979187 8 Gemeinhart RA, Luo D, Saltzman WM. Cellular fate of a modular DNA delivery system mediated by silica nanoparticles. Biotechnology Progress 21(2): 532-537, 2005. 10.1021/bp049648w 15801794 7 Tan J, Gemeinhart RA, Ma M, Saltzman WM. Improved cell adhesion and proliferation on synthetic phosphonic acid-containing hydrogels. Biomaterials 26(17): 3663-3671, 2005. 10.1016/j.biomaterials.2004.09.053 15621257 6 Kang CE, Gemeinhart EJ,Gemeinhart RA. Celluar alignment by grafted adhesion peptide surface density gradients. Journal of Biomedical Materials Research 71(3): 403-411, 2004. 10.1002/jbm.a.30137 15481057 5 Guo C, Gemeinhart RA. Assessment of a modular transfection mechanism based upon cellular localization of DNA. Molecular Pharmaceutics 1(4): 309-316, 2004. 10.1021/mp049969a 15981590 4 Gemeinhart RA, Park H, Park K. Effect of compression on fast swelling of poly(acrylamide-co-acrylic acid) superporous hydrogels. Journal of Biomedical Materials Research 55(1): 54-62, 2001. 10.1002/1097-4636(200104)55:13.0.co;2-y 11426398 3 Gemeinhart RA, Chen J, Park H, Park K. pH-Sensitivity of fast responsive superporous hydrogels. Journal of Biomaterials Science, Polymer Edition 11(12): 1371-1380, 2000. 10.1163/156856200744390 11261878 2 Gemeinhart RA, Park H, Park K. Pore structure of superporous hydrogels. Polymers for Advanced Technologies 11(8-12): 617-625, 2000. 10.1002/1099-1581(200008/12)11:8/12%3C617::AID-PAT12%3E3.0.CO;2-L 1 Park K, Gemeinhart RA, Park H. Movement of fibrinogen receptors on the ventral membranes of spreading platelets. Biomaterials 19(4-5): 387-395, 1998. 10.1016/S0142-9612(97)00111-7 9677152 -
Book Chapters
- Zamiri C, Gemeinhart RA. Drug Delivery Systems for Pulmonary Delivery of Therapeutic Biomacromolecules, in Pharmaceutical Biotechnology, Second Edition, Ed. Groves MJ. Boca Raton, FL: CRC Press; 2005, 255-277.
- Gemeinhart RA. Polymers for Oral Biomolecule Delivery, in Pharmaceutical Biotechnology, Second Edition, Second Edition, Ed. Groves MJ. Boca Raton, FL: CRC Press; 2005, 279-302.
- Gemeinhart RA, Guo C. Fast Swelling Hydrogel Systems, in Reflexive polymers and hydrogels: Understanding and designing fast-responsive polymeric systems, edited by Yui N, Mrsny R, Park K, 2004.
- Rayahin JE, Gemeinhart RA. Activation of Macrophages in Response to Biomaterials. In: Kloc M (ed) Macrophages – Origin, functions and biointervention part of the Results and problems in cell differentiation series. Springer, New York. 2017, Volume 62, Chapter 13, 317-351. DOI & Pubmed
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Patents
- Gemeinhart RA, Buhrman JS, Rayahin JE. Hydrogels for Delivery of Therapeutic Polypeptides, US 9,457,101B2 (October 4, 2016). USPTO
- Cho MR, Kadakia A, Djilian A, Gemeinhart RA. Hybrid Superporous Hydrogel Scaffold for Cornea Regeneration. Patent Application, 2010/80,840A1 (April 1, 2010). USPTO
- Gemeinhart RA. Superporous Hydrogel with Cells Encapsulated Therein and Method for Producing the Same. US 8,414,879B2 (April 9, 2013). USPTO
- Gemeinhart RA, Tauro JR. Composition and Method for Providing Localized Delivery of a Therapeutic Agent. US 7,943,569 (May 17, 2011). USPTO